Oxycodone and acetaminophen combination can cause significant unwanted effects or fatal overdose if taken by little ones, pets, or adults who are not used to robust opioid pain medicines. Make confident you keep the medicine in a very safe and safe place to avoid others from finding it.
If opioid use is necessary for your prolonged period within a pregnant woman, suggest the patient with the risk of neonatal opioid withdrawal syndrome and make sure ideal treatment are going to be readily available [see WARNINGS].
Recommend patients who will be taken care of with PERCOCET For additional than a number of weeks not to abruptly discontinue the medication. Recommend patients to refer to with their medical professional for the gradual discontinuation dose schedule to taper off the medication.
If concomitant use is warranted, check patients for signs of respiratory depression Which might be increased than otherwise anticipated and reduce the dosage of oxycodone and acetaminophen tablets and/or maybe the muscle mass relaxant as essential.
Nursing Mothers Accessible information from lactation scientific studies point out that oxycodone is current in breastmilk and that doses of much less than sixty mg/day from the fast-release formulation are unlikely to end in clinically pertinent exposures in breastfed infants.
Oxycodone and acetaminophen tablets may impair the psychological or Actual physical talents required to accomplish potentially dangerous pursuits which include driving a car or operating equipment.
The concomitant usage of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, might reduce the analgesic effect of oxycodone and acetaminophen tablets and/or precipitate withdrawal symptoms.
If your response to an opioid antagonist is suboptimal or only short in character, administer more antagonist as directed because of the product's prescribing information.
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Keep all appointments with your physician. Your health practitioner may well purchase specific lab tests to check your entire body's response to oxycodone.
Serotonin syndrome: Situations of serotonin syndrome, a potentially life-threatening problem, have been reported during concomitant utilization of opioids with serotonergic drugs.
Instruct patients to look for acetaminophen or APAP on bundle labels instead of to use additional than 1 merchandise which contains acetaminophen. Instruct patients to hunt medical notice immediately upon ingestion of much more than 4,000 milligrams of acetaminophen a day, even should they feel nicely.
Therapeutic doses of acetaminophen have negligible effects to the cardiovascular or respiratory systems; having said that, harmful doses may percocet brand cause circulatory failure and rapid, shallow breathing.
If concomitant use is essential, consider rising the oxycodone and acetaminophen tablets dosage until finally stable drug effects are obtained.